PRP vs. PRF: What's the Difference and Which Is Better for Aesthetic Treatments?

The terms "PRP" and "PRF" can  get confusing. Some people use the two terms interchangeably and the difference needs to be defined so you can make informed choices regarding your aesthetic treatments. PRP (Platelet-Rich Plasma) and PRF (Platelet-Rich Fibrin) are powerful, natural treatment options, especially when it comes to using them with undereye rejuvenation, scalp treatments for hair loss, and microneedling for skin revitalization.

Both PRP and PRF use your body’s own platelets and growth factors to stimulate healing and regeneration, but they work in slightly different ways. Here's a breakdown to help you understand the science, the benefits, and which might be the best choice for your skin or hair goals!

What is PRP?

PRP (Platelet-Rich Plasma) is a regenerative treatment that uses your own blood. After drawing a small amount of blood, we spin it in a centrifuge to isolate the platelet-rich plasma, which is rich in growth factors. These growth factors stimulate tissue regeneration, collagen production, and healing.

Common PRP & PRF Uses in Aesthetics:

• Under-eye hollows: Improves skin texture and elasticity, reduces crepey skin and dark circles.

• Scalp rejuvenation: Stimulates dormant hair follicles for fuller, healthier hair growth.

• Microneedling: When combined with microneedling, PRP/PRF enhances healing and boosts collagen.

What is PRF?

PRF (Platelet-Rich Fibrin) is the next generation of PRP. It’s also derived from your blood, but spun at a lower speed without anticoagulants. This slower spin allows more of the white blood cells, fibrin matrix, and stem cells to remain in the serum, resulting in a slower release of growth factors over time.

Think of PRF as a more natural and long-lasting version of PRP. If you want a deeper dive on the differences, you can read this article by the International Fellowship in Advanced Aesthetic Science. 

Key Differences Between PRP and PRF:

Feature	PRP	PRF
Additives	Uses anticoagulants	100% natural, no additives
Growth Factor Release	Quick burst	Slow, sustained release
Cell Content	Mostly platelets	Platelets, WBCs, stem cells, fibrin
Texture	Liquid	Gel-like fibrin matrix

Under-Eye Rejuvenation: PRF Takes the Lead

While both PRP and PRF can be used for under-eye rejuvenation, PRF is often the preferred choice due to its longer-lasting results and higher concentration of healing cells. The natural fibrin matrix acts like a scaffold, holding the growth factors in place longer, resulting in smoother, firmer skin with less crepiness and discoloration.

Scalp Treatments: PRP vs PRF for Hair Restoration

For hair restoration, both treatments stimulate the scalp and promote hair growth. However, PRF may offer superior results due to its more concentrated regenerative components and slower release. That said, PRP has been studied longer and remains an effective option, especially when done in a series.

At my Idaho Falls medspa location, I will talk with you and assess your scalp in person so we can define realistic hair goals, understand your current scalp condition, and review your treatment and medical history before deciding which to use.

Microneedling: Enhanced Results with PRP or PRF

Combining microneedling with PRP or PRF is one of the most powerful skin rejuvenation therapies available. The microneedles create micro-channels in the skin, allowing the platelet-rich serum to penetrate deeply and promote healing.

• PRP with microneedling: Speeds up healing and collagen stimulation.

• PRF with microneedling: Provides deeper, longer-lasting rejuvenation with added stem cells and sustained growth factor release.

Which One Is Right for You?

Choosing between PRP and PRF depends on your goals, treatment area, and preferences. At my Idaho Falls aesthetics clinic, I provide a full consultation to determine the best plan for your unique skin or hair needs.

Both treatments are:

• Non-surgical

• Natural (using your body’s own healing powers)

• Minimal downtime

• Safe and effective for most skin types

Final Thoughts

Whether you're looking to restore volume under your eyes, stimulate hair growth, or rejuvenate your skin with microneedling, both PRP and PRF are powerful, natural options. PRF is newer and often offers longer-lasting benefits, but PRP is still widely trusted and effective.

If you're curious about these treatments or want to explore your options with an experienced nurse injector in Idaho Falls, I’d love to help guide your journey. Book your consultation today and let’s unlock your skin’s potential - naturally.